Knowledge Synthesis

About CHI Knowledge Synthesis

The Knowledge Synthesis (KS) platform is focused on increasing Manitoba’s capacity to synthesize knowledge to inform public policy, improve service delivery and optimize Manitobans’ health. Services range from complete management of KS projects for academic publication to consultation on particular aspects of the KS pathway. Other services include KS-related training, informing funding applications, and guiding health policy decision making.

Our Services

Our expert team of methodologists, systematic reviewers, academicians, biostatisticians and librarians will collaborate with you to produce:

  • Systematic reviews & meta-analyses
  • Evidence summaries
  • Rapid reviews for government & decision makers
  • Diagnostic accuracy reviews
  • Methodological reviews, economic reviews
  • Observational reviews
  • Other services (expert advice, review registration, search strategies, etc.)


KS platform scientists lead and participate in a variety of projects to improve patient outcomes, including:

  • Systematic reviews of health interventions
  • Innovative methods to conduct knowledge synthesis projects
  • Observational reviews on provocative topics
  • Health system reviews
  • Health technology assessments

Our Team


Dr. Ahmed Abou-Setta is currently a Research Associate at The George and Fay Yee Centre for Healthcare Innovation, University of Manitoba/ Winnipeg Regional Health Authority. In this role, he leads and supports knowledge synthesis projects including clinical guideline preparation, systematic reviews, overviews of reviews and related activities. In addition, Dr. Abou-Setta is leading innovative research into methods for improving and streamlining the systematic review process including the use of computer-assisted screening and probability-based classification of citations, increasing visual identification of key terms using system-generated font and color contrast, computer-assisted literature search strategy production, and semi-automated report preparation. Furthermore, Dr. Abou-Setta is involved in continuous education to clinical faculty at the University of Manitoba and students through epidemiological and biostatistical consultation, teaching, and collaborative innovative research on knowledge synthesis projects.

Dr. Abou-Setta’s areas of research expertise includes clinical epidemiological research methods, methods for evaluation of the quality of data from clinical trials, the meta-analysis of trial data, and methods for utilizing indirect evidence. He has engaged in research synthesis, data analysis, meta-analysis, interpretation, presentation and review and methodology consultations with different groups from all over the world, including collaborating with world-renowned clinicians, epidemiologists and researchers, including members of The Egyptian and Middle East IVF registries, and the International Committee for Monitoring IVF. Most recently, he has completed a postdoctoral fellowship at the University of Alberta’s Evidence-based Practice Centre, where he led multiple teams of review authors to investigate important clinical questions in the context of comparative effectiveness reviews and methodological reviews.

Dr. Abou-Setta combines unique insights as both a clinician and post-doctorate level researcher with research experience in various clinical settings. These clinical topics are broad and have included reproductive endocrinology, pain management in elderly patients with hip fractures, management strategies in hypercholesterolemic patients, antipsychotic management of adults with schizophrenia and bipolar disorder, management of male impotence, and prevention of premature ovarian failure in women undergoing chemotherapy.

Dr. Abou-Setta is highly committed to creating and sustaining educational opportunities and training in the knowledge and skills essential to undertake knowledge synthesis projects. As none were available at the University of Manitoba, Dr. Abou-Setta has been co-teaching the first accredited systematic review course where graduate students and clinicians at the University of Manitoba are being trained to produce high-quality systematic reviews of the literature. In addition, Dr. Abou-Setta is exploring opportunities to collaborate with well-established organization like the Cochrane Collaboration and other Canadian Universities to provide local training to the University of Manitoba’s members, especially in advanced methods like network meta-analysis, individual patient meta-analysis and rapid reviews.

The excellence of Dr. Abou-Setta’s research agenda has been recognized through frequent presentation of results at international venues including the Cochrane Colloquium, multiple publications in top-ranked peer-reviewed journals including the JAMA, Annals of Internal Medicine, Cochrane Library, and publications having been cited over 600 times (H-index = 14).

Director, Knowledge Synthesis platform

tel: 204.594.5357
fax: 204.594.5394


Maya Jeyaraman, MD, PhD

Senior Systematic Reviewer

tel: 204.594.5362
fax: 204.594.5394


George Okoli

Senior Systematic Reviewer

tel: 204.594.5347
fax: 204.594.5394


Leslie joined the Knowledge Synthesis platform in January 2015 after having earned the Master of Public Health degree at the University of Manitoba in 2014. She is also an international medical graduate with a Master of Science in Nephrology, earned in Brazil. Her current research interests are knowledge synthesis in clinical interventions, public health interventions and health care management and policies.

Systematic Reviewer

tel: 2044306504


Otto Lam, BSc, BDS (Hons), MEd, PhD, ACRP-CP

Systematic Reviewer



Viraj Kasireddy, MD, MPH

Systematic Reviewer

tel: 204.594.5378

High-impact journal reviews

2018 Clinical Practice Guideline on Screening for Colorectal Cancer in individuals with a Family History of Nonhereditary Colorectal Cancer or Adenoma: The Canadian Association of Gastroenterology Banff Consensus.

Gastroenterology, Undefined,

Desmond Leddin, David A Lieberman, Frances Tse, Alan N Barkun, Ahmed M Abou-Setta, John K Marshall, N Jewel Samadder, Harminder Singh, Jennifer J Telford, Jill Tinmouth, Anna N Wilkinson, Grigorios I Leontiadis

Show in PubMed - PMID:30121253

2017 Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, Undefined, 28

Meghan B Azad, Ahmed M Abou-Setta, Bhupendrasinh F Chauhan, Rasheda Rabbani, Justin Lys, Leslie Copstein, Amrinder Mann, Maya M Jeyaraman, Ashleigh E Reid, Michelle Fiander, Dylan S MacKay, Jon McGavock, Brandy Wicklow, Ryan Zarychanski

Show in PubMed - PMID:28716847

2013 Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis.

JAMA, Undefined, 7

Ryan Zarychanski, Ahmed M Abou-Setta, Alexis F Turgeon, Brett L Houston, Lauralyn McIntyre, John C Marshall, Dean A Fergusson

Show in PubMed - PMID:23423413

2013 Probiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: systematic review and meta-analysis.

BMJ (Clinical research ed.), Undefined,

Meghan B Azad, J Gerard Coneys, Anita L Kozyrskyj, Catherine J Field, Clare D Ramsey, Allan B Becker, Carol Friesen, Ahmed M Abou-Setta, Ryan Zarychanski

Show in PubMed - PMID:24304677

Cochrane Reviews

2016 Ultrasound versus 'clinical touch' for catheter guidance during embryo transfer in women.

The Cochrane database of systematic reviews, Undefined,

Julie Brown, Karen Buckingham, William Buckett, Ahmed M Abou-Setta

Show in PubMed - PMID:26984325

2016 Recombinant versus urinary human chorionic gonadotrophin for final oocyte maturation triggering in IVF and ICSI cycles.

The Cochrane database of systematic reviews, Undefined,

Mohamed A Youssef, Ahmed M Abou-Setta, Wai Sun Lam

Show in PubMed - PMID:27106604