CIHR STAGE: International Speaker Seminar Series: Mapping the structure of genetic risk for common disease in the UK Biobank


CIHR STAGE: International Speaker Seminar Series: Mapping the structure of genetic risk for common disease in the UK Biobank

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June 07, 2019 - 10:55 - 12:00
Team: Events, Training & News
Posted on May 24, 2019

CHIMb.ca
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CIHR STAGE: International Speaker Seminar Series: Mapping the structure of genetic risk for common disease in the UK Biobank

Team: Events, Training & News

June 07, 2019 - 10:55 - 12:00

Description


Genetic risk factors frequently affect multiple common human diseases, providing insight into shared pathophysiological pathways and opportunities for therapeutic development. However, systematic identification of genetic profiles of disease risk is limited by the availability of both comprehensive clinical data on population-scale cohorts and the lack of suitable statistical methodology that can handle the scale of and differential power inherent in multi-phenotype data. We have developed a disease-agnostic approach to cluster genetic risk profiles for 3,025 genome-wide independent loci across 19,155 ICD-10 diagnostic codes from 320,644 participants in the UK Biobank, representing a large and heterogeneous population. We identify several hundred distinct disease association profiles and use multiple approaches to link clusters to underlying biological pathways. We show how clusters can decompose the variance and covariance in risk for disease, thereby identifying underlying biological processes and their impact. We demonstrate the use of clusters in defining disease relationships and informing therapeutic strategies. 

 

Featuring:

Dr. Gil McVean

Professor of Statistical Genetics, University of Oxford

Director, Big Data Institute, University of Oxford


The George & Fay Yee Centre for Healthcare Innovation is hosting the CIHR STAGE (Strategic Training for Advanced Genetic Epidemiology) International speaker Monthly Seminar Series. This is a formal and comprehensive training program in Genetic Epidemiology and Statistical Genetics.

CIHR STAGE aims to expose trainees to high-calibre international research and foster a cohesive research community of genetic epidemiologists, statistical geneticists and bioinformatician in Canada through this series, and in the context of genetic epidemiology, statistical genetics and bioinformatics research.

This session will be offered via webcast (the live session will take place in Toronto).

Please submit any questions via email to pingzhao.hu@umanitoba.ca

 

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