Round: Human Microbiome Data Methodology and Analysis


Round: Human Microbiome Data Methodology and Analysis

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September 17, 13:30 - September 26, 14:30, 2019
Team: Events, Training & News
Posted on August 26, 2019

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Round: Human Microbiome Data Methodology and Analysis

Team: Events, Training & News

September 17, 13:30 - September 26, 14:30, 2019

Description


Biostatistics Round
Human Microbiome Data Methodology and Analysis

Presenter: Dr. Wei Xu, University of Toronto /Princess Margaret Cancer Centre

September 17, 2019
1:30 pm - 2:30 pm 
Room A315, 3rd Floor, Chown Building, 753 McDermot Ave

Human microbiome, including the microorganism within the body and its environment, is a big topic and has been explored for decades. However, our understanding of how microbiomes affect diseases is still unclear. Recent genomic sequencing technologies have enabled researchers to unveil the wide variability of bacteria presented within different locations of the body, i.e. the microbiome, and how it relates to human diseases.  It is necessary to better understand how both environmental and host genetic factors impact the composition of the microbiome to improve diagnosis and disease management. Efficient statistical and bioinformatics tools are needed to overcome these knowledge gaps. In this talk, I will introduce some general characteristics of the human microbiome sequencing data that can be clustered into operational taxonomic units (OTUs) at each taxonomic level by next-generation sequencing. Several analytic approaches will be introduced to summarize and assess the single or multiple OTUs and genetic risk factors using different methods. Specific features of the microbiome sequencing data will be explored such as non-negative, highly skewed sequence counts with excess zeros, and clustered taxonomic structure

Biostatistics Group Business Meeting to follow from 2:30 pm - 3:30 pm with an open discussion on experiences, challenges, and opportunities involving clinical trials.

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