Knowledge Synthesis


About CHI Knowledge Synthesis

The Knowledge Synthesis (KS) platform is focused on increasing Manitoba’s capacity to synthesize knowledge to inform public policy, improve service delivery and optimize Manitobans’ health. Services range from complete management of KS projects for academic publication to consultation on particular aspects of the KS pathway. Other services include KS-related training, informing funding applications, and guiding health policy decision making.

Our Services

Our expert team of methodologists, systematic reviewers, academicians, biostatisticians and librarians will collaborate with you to produce:

  • Systematic reviews & meta-analyses
  • Evidence summaries
  • Rapid reviews for government & decision makers
  • Diagnostic accuracy reviews
  • Methodological reviews, economic reviews
  • Observational reviews
  • Other services (expert advice, review registration, search strategies, etc.)

Research

KS platform scientists lead and participate in a variety of projects to improve patient outcomes, including:

  • Systematic reviews of health interventions
  • Innovative methods to conduct knowledge synthesis projects
  • Observational reviews on provocative topics
  • Health system reviews
  • Health technology assessments

Our Team

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Ryan Zarychanski, MD, MSc. FRCPC

Associate Director, Knowledge Synthesis

tel: 204.787.1992
fax: 204.786.0196
email: ryan.Zarychanski@cancercare.mb.ca


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Ahmed Abou-Setta, MD, PhD

Knowledge Synthesis Unit Manager and Review Manager

Dr. Ahmed Abou-Setta is currently a Research Associate at The George and Fay Yee Centre for Healthcare Innovation, University of Manitoba/ Winnipeg Regional Health Authority. In this role, he leads and supports knowledge synthesis projects including clinical guideline preparation, systematic reviews, overviews of reviews and related activities. In addition, Dr. Abou-Setta is leading innovative research into methods for improving and streamlining the systematic review process including the use of computer-assisted screening and probability-based classification of citations, increasing visual identification of key terms using system-generated font and color contrast, computer-assisted literature search strategy production, and semi-automated report preparation. Furthermore, Dr. Abou-Setta is involved in continuous education to clinical faculty at the University of Manitoba and students through epidemiological and biostatistical consultation, teaching, and collaborative innovative research on knowledge synthesis projects.

Dr. Abou-Setta’s areas of research expertise includes clinical epidemiological research methods, methods for evaluation of the quality of data from clinical trials, the meta-analysis of trial data, and methods for utilizing indirect evidence. He has engaged in research synthesis, data analysis, meta-analysis, interpretation, presentation and review and methodology consultations with different groups from all over the world, including collaborating with world-renowned clinicians, epidemiologists and researchers, including members of The Egyptian and Middle East IVF registries, and the International Committee for Monitoring IVF. Most recently, he has completed a postdoctoral fellowship at the University of Alberta’s Evidence-based Practice Centre, where he led multiple teams of review authors to investigate important clinical questions in the context of comparative effectiveness reviews and methodological reviews.

Dr. Abou-Setta combines unique insights as both a clinician and post-doctorate level researcher with research experience in various clinical settings. These clinical topics are broad and have included reproductive endocrinology, pain management in elderly patients with hip fractures, management strategies in hypercholesterolemic patients, antipsychotic management of adults with schizophrenia and bipolar disorder, management of male impotence, and prevention of premature ovarian failure in women undergoing chemotherapy.

Dr. Abou-Setta is highly committed to creating and sustaining educational opportunities and training in the knowledge and skills essential to undertake knowledge synthesis projects. As none were available at the University of Manitoba, Dr. Abou-Setta has been co-teaching the first accredited systematic review course where graduate students and clinicians at the University of Manitoba are being trained to produce high-quality systematic reviews of the literature. In addition, Dr. Abou-Setta is exploring opportunities to collaborate with well-established organization like the Cochrane Collaboration and other Canadian Universities to provide local training to the University of Manitoba’s members, especially in advanced methods like network meta-analysis, individual patient meta-analysis and rapid reviews.

The excellence of Dr. Abou-Setta’s research agenda has been recognized through frequent presentation of results at international venues including the Cochrane Colloquium, multiple publications in top-ranked peer-reviewed journals including the JAMA, Annals of Internal Medicine, Cochrane Library, and publications having been cited over 600 times (H-index = 14).

tel: 204.594.5357
fax: 204.594.5394
email: Ahmed.Abou-setta@umanitoba.ca


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Maya Jeyaraman, MD, PhD

Research Associate & Review Manager

tel: 204.594.5362
fax: 204.594.5394
email: maya.jeyaraman@umanitoba.ca


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George Okoli

Research Associate & Review Manager

tel: 204.594.5347
fax: 204.594.5394
email: george.okoli@umanitoba.ca


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Christine Neilson, BSc, MLIS

Knowledge Synthesis Librarian

Christine joined the George and Fay Yee Centre for Healthcare Innovation (CHI) in August 2016. As the Knowledge Synthesis Librarian, she works with KS staff and investigators on various research projects. She also teaches the literature searching portion of the Systematic Reviews and Meta-Analysis Course that is offered through CHI.

Christine holds a Bachelor of Science (BSc) degree from the University of Manitoba and a Master of Library and Information Studies (MLIS) from the University of Alberta, and she has worked as a health librarian since 2003. She splits her time between CHI and the Neil John Maclean Health Sciences Library.

email: Christine.Neilson@umanitoba.ca


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Leslie Copstein, MSc, MPH

Research Assistant

Leslie has been working as a Research Assistant at the Knowledge Synthesis platform since January 2015. She is an international medical graduate, having received her degree in Medicine in Brazil in 1993, and completed her residency in Internal Medicine and Nephrology. She obtained a Master of Science in Nephrology in 2006 at the Universidade Federal do Rio Grande do Sul, in Brazil, and a Master of Public Health in 2014, at the University of Manitoba. Her present research interests include systematic reviews and knowledge synthesis and translation.

email: Leslie.Copstein@umanitoba.ca


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Farnaz Farshidfar , MD, MSc

Research Assistant

Farnaz Farshidfar joined the George and Fay Yee Centre for Healthcare Innovation (CHI) as a Research Assistant in the Knowledge Synthesis Platform in May 2016. Farnaz received her Doctorate of Medicine (MD) from Isfahan University of Medical Sciences, Iran, in 2009 and completed her Master of Sciences in Human Nutritional Sciences at University of Manitoba in 2016. Farnaz is passionate about biomedical and translational research and implementation of up-to-date clinical researches in current medical protocols.

email: farshidf@myumanitoba.ca


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Hessam H. Kashani

Research Assistant

Hessam Kashani joined the George and Fay Yee Centre for Healthcare Innovation (CHI) as a Research Assistant in the Knowledge Synthesis Platform in May 2016. Hessam received his Doctorate of Medicine (MD) from Isfahan University of Medical Sciences, Iran, in 2008 and completed his Master of Sciences in the Department of Physiology and Pathophysiology at University of Manitoba in 2013. Hessam is passionate about biomedical and translational research and implementation of up-to-date clinical researches in current medical protocols.

email: umkashan@myumanitoba.ca


High-impact journal reviews

2017 Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, Undefined, 28

Meghan B Azad, Ahmed M Abou-Setta, Bhupendrasinh F Chauhan, Rasheda Rabbani, Justin Lys, Leslie Copstein, Amrinder Mann, Maya M Jeyaraman, Ashleigh E Reid, Michelle Fiander, Dylan S MacKay, Jon McGavock, Brandy Wicklow, Ryan Zarychanski

Show in PubMed - PMID:28716847

2013 Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis.

JAMA, Undefined, 7

Ryan Zarychanski, Ahmed M Abou-Setta, Alexis F Turgeon, Brett L Houston, Lauralyn McIntyre, John C Marshall, Dean A Fergusson

Show in PubMed - PMID:23423413

2013 Probiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: systematic review and meta-analysis.

BMJ (Clinical research ed.), Undefined,

Meghan B Azad, J Gerard Coneys, Anita L Kozyrskyj, Catherine J Field, Clare D Ramsey, Allan B Becker, Carol Friesen, Ahmed M Abou-Setta, Ryan Zarychanski

Show in PubMed - PMID:24304677

Cochrane Reviews

2016 Ultrasound versus 'clinical touch' for catheter guidance during embryo transfer in women.

The Cochrane database of systematic reviews, Undefined,

Julie Brown, Karen Buckingham, William Buckett, Ahmed M Abou-Setta

Show in PubMed - PMID:26984325

2016 Recombinant versus urinary human chorionic gonadotrophin for final oocyte maturation triggering in IVF and ICSI cycles.

The Cochrane database of systematic reviews, Undefined,

Mohamed A Youssef, Ahmed M Abou-Setta, Wai Sun Lam

Show in PubMed - PMID:27106604