News: Dr. Pingzhao Hu's Project 'Personalized Medicin...


News: Dr. Pingzhao Hu's Project 'Personalized Medicine Approaches for IBD' Wins Poster of Distinction

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May 26, 2017, 07:55
Team: Events, Training & News

CHIMb.ca
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News: Dr. Pingzhao Hu's Project 'Personalized Medicine Approaches for IBD' Wins Poster of Distinction

Team: Events, Training & News

May 26, 2017, 07:55

Description


CHI Data Science's Dr. Pingzhao Hu worked in collaboration with Diagnostic Services of Manitoba and University of Manitoba Inflammatory Bowel Disease (IBD) Clinical and Research Centre to identify genes significantly associated with IBD. The project applied genome-wide approaches to identify copy number variation (CNV) biomarkers to enable a more individually tailored approach to diagnosis and treatment of inflammatory bowel disease.

Project researchers performed genome-wide genotyping of 280 patients with IBD from The Manitoba IBD Cohort Study. Copy number variation (CNV) analysis identified 16 rare recurrent CNV regions significantly associated with IBD, which intersected 41 genes. One of the most interesting CNV regions identified is 1q23.3. This genomic region was also repeatedly observed which suggested associations with the broad array of autoimmune disorders, such as systemic lupus erythematosus, glomerulonephritis, rheumatoid arthritis, and other autoimmune diseases.

Of the 41 genes identified, 24 are functionally related to the interactions between host immune system and gut microbiome, including DEFB genes family, FCGR2B, GSTM1, RAC1, GTF2F1, PSPN and other. Remarkably, gene FCGR2B in the region encodes the only inhibitory IgG receptor in FCGR gene family while the other genes in the group encode activating receptors, suggesting a potential target for developing personalized drugs for IBD.

This finding won the "Poster of Distinction” award at American Gastroenterological Association’s (AGA) Digestive Disease Week (DDW). This poster was rated in the top 10 per cent of all AGA abstracts selected for poster presentation at DDW which took place in Chicago, Illinois from May 6 to May 9, 2017.

CHI Data Science platform worked on the project which was funded through Health Sciences Centre Foundation and Mitacs. Co-investigators were Dr. Charles Bernstein & Dr. Beth Spriggs with collaboration from Dr. John Wilkins.